Bacterial celluloseTiO

titanium dioxide yeast
2022 04-02 05:31

nanocomposites promote healing and tissue regeneration in burn mice model

aBiotechnology Program, COMSATS Institute of Information Technology, Abbottabad-22060, Pakistan

bDepartment of Pharmacy, COMSATS Institute of Information Technology, Abbottabad-22060, Pakistan

cDepartment of Chemical Engineering, College of Engineering, Dhofar University, Salalah, Oman

dDepartment of Environmental Sciences, COMSATS Institute of Information Technology, Abbottabad-22060, Pakistan

eDepartment of Chemical Engineering, Kyungpook National University, Daegu, Korea

fDepartment of Pathology, Ayub Medical College, Abbottabad, Pakistan

The development of novel cutaneous wound treatments particularly for burns is of paramount importance due to complex pathophysiology, prevalent infection and clinical complexities associated with burn care. The main focus of the current study was to investigate thein vivoburn wound healing potential of bacterial cellulose (BC) and titanium dioxide (TiO2) nanocomposites (BCTiO2). The physicochemical characterization of BCTiO2was carried out using FE-SEM, XRD and FT-IR. The antimicrobial activity of the nanocomposite was tested againstEscherichia coliandStaphylococcus aureusthrough agar disc diffusion protocol. Thein vivowound healing efficacy was evaluated in burn wound model through wound area measurement, percent contraction and histopathology. The characterization results confirmed the successful incorporation of TiO2nanoparticles into BC. The nanocomposites exhibited 81 0.4% and 83 0% inhibition againstE. coliandS. aureus, respectively. The composite bandage showed good healing pattern with 71 2.41% wound contraction. Histopathological evidence like the formation of healthy granulation tissue and the re-epithelization indicated the healing progression in the composite treated group. In comparison, the BC treated group has partial epithelization and signs of inflammation. These results proved that the composite dressing possesses an excellent healing potential with faster re-epithelization rate and accelerated wound contraction ability and thus could be a candidate for the development of cutaneous wound care products to address the limitations of the conventional wound dressing for burns.

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A. Khalid, H. Ullah, M. Ul-Islam, R. Khan, S. Khan, F. Ahmad, T. Khan and F. Wahid,RSC Adv., 2017,7, 47662DOI:10.1039/C7RA06699F

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